My research efforts focus on 1) Investigate the role of physical activity and exercise training in preventing or ameliorating vascular (endothelial) dysfunction in pathophysiologic conditions such as obesity, type 2 diabetes, ischemic heart disease, hypertension, aging (Alzheimer), microgravity, etc. in animal and human subjects, and 2) Elucidating the mechanisms in which vascular function is altered by the sequelae of the diseases and physical activity/exercise training at the molecular, cellular, and intact tissue levels (isolated intact microvessels).
